This invention relates to a method of treating cancer by administering a combination therapy comprising a combination of a MEK inhibitor and a PD-1 axis binding antagonist, or a combination of a MEK inhibitor and a PARP inhibitor, or a combination of a MEK inhibitor and a PD-1 axis binding antagonist and a PARP inhibitor to a patient in need thereof.本發明關於藉由投予組合療法來治療癌症之方法,該組合療法包含投予有此需要之患者MEK抑制劑和PD-1軸結合拮抗劑之組合、或MEK抑制劑和PARP抑制劑之組合、或MEK抑制劑和PD-1軸結合拮抗劑及PARP抑制劑之組合。