作為體內造血刺激劑之TAT-HOXB4H重組蛋白質之製造方法

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专利权人:

台灣尖端先進生技醫藥股份有限公司;TAIWAN ADVANCE BIO-PHARM INC.

发明人:

Wu, Kou-Juey,Huang, Chi-Hung,吳國瑞,黃濟鴻

申请号：

HK12111667.5

公开号：

HK1170933B

申请日:

2009.10.12

申请国别(地区):

HK

年份:

2017

代理人:

摘要：

The present invention relates to a new and nonobvious method of producing the C-terminal histidine tagged TAT-HOXB4 fusion protein (TAT-HOXB4H), providing unexpected benefits of increased yield and stability to allow for in vivo administration of this protein, and pharmaceutical composition comprising an effective ingredient, TAT-HOXB4H, having stimulatory activity on the production of hematopoietic cells. More specifically, recombinant TAT-HOXB4H protein enhances engraftment of bone marrow transplants, hematopoietic reconstruction, bone marrow re-population and number of circulating stem cells, particularly after chemotherapy or irradiation.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/