A method of using a medical fluid injector (10) and a syringe (16), the method comprising inserting a syringe, having a longitudinal reference axis, into an aperture defined in the injector while the syringe is located within the aperture in the injector, positioning at least a portion (28) of a plunger of the syringe such that it is received between first and second gripper members (92) of the injector, and such that at least one of the first and second gripper members is in contact with at least a portion of the plunger, wherein the positioning comprises pivoting the first and second gripper members (92) about a common pivot axis (95).