Cyclic peptides, method for preparing and use as angiogenesis inhibitors or activators

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专利权人:

Andreas Bikfalvi

发明人:

Natacha Betz,Andreas Bikfalvi,Gerard Deleris

申请号：

US12418101

公开号：

USRE044022E1

申请日:

2001.10.02

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The invention relates to cyclopeptides, the method of their preparation and their utilization as inhibitors or activators of angiogenesis.These cyclopeptides comprisecontain the following peptide sequence:-Arg-Ile-Lys-Pro-His-Gln-Gly-   (SEQ ID NO: 1).They can be used in systems for inhibition of angiogenesis that comprisesinclude a support (1), to which the cyclopeptide is affixed by means ofcoupled via an organic spacer arm (3) that may be provided with a moiety (4) capable of being splicedcleaved by an enzyme system.

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