QUEEN'S UNIVERSITY AT KINGSTON;GEORGIA TECH RESEARCH CORPORATION;KINGSTON HEALTH SCIENCES CENTRE;EMORY UNIVERSITY
发明人:
ZAKAS, PHILIP,LILLICRAP, DAVID,DOERING, CHRISTOPHER,GAUCHER, ERIC,RADFORD, CAELAN,SPENCER, HAROLD TRENT
申请号：
CA3081106
公开号：
CA3081106A1
申请日:
2018.11.01
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
A recombinant von Willebrand Factor (VWF) protein comprising one or more mutations and uses thereof are described. A recombinant protein complex comprising a von Willebrand factor sequence and one artificial Factor VIII sequence is described. A recombinant protein complex comprising a Factor VIII sequence and one artificial von Willebrand sequence is described. A recombinant protein complex is described that includes one artificial von Willebrand factor sequence and one artificial Factor VIII sequence. Also described are nucleic acid sequences and a vector encoding a VWF sequence and a pharmaceutical composition for inducing blood clotting that includes a VWF protein.
