Cornelis Johannes Leenhouts;Ronald de Groot;Peter Wilhelmus Maria Hermans
发明人:
Cornelis Johannes Leenhouts,Ronald de Groot,Peter Wilhelmus Maria Hermans
申请号：
US10556733
公开号：
US08142789B2
申请日:
2004.05.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to the field of biology, more specifically to the field of immunology and microbiology. The invention further relates to the field of vaccines against microbial infections and especially bacterial vaccines, in particular to pneumococcal vaccines. More in particular, the invention relates to means and methods to identify, select and isolate a vaccine component for passive and/or active immunisation against a microorganism that can be killed by opsonophagocytic cells. The invention relates to a method to identify an opsonophagocytosis inducing antigen as a vaccine component for immunisation against a microorganism. The invention describes three pneumococcal proteins SlrA, IgAl proteinase, and PsaA, and their use as a vaccine component with or without PpmA. The invention also discloses the use of antibodies against said proteins for passive immunization and diagnosis.
