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Beta-lactamase inhibitor and process for preparing the same
专利权人:
发明人:
Takao Abe,Takeshi Furuuchi,Yoshiaki Sakamaki
申请号:
US14404288
公开号:
US09181250B2
申请日:
2013.05.30
申请国别(地区):
US
年份:
2015
代理人:
摘要:
A diazabicyclooctane compound, which is a beta-lactame inhibitor, represented by the following formula (I):wherein A represents Ra(Rb)N— or RcO— B represents NH or NC1-6 alkyl C represents benzyl, H or SO3M, wherein M represents H, an inorganic or an organic cation Ra and Rb represent H, C1-6 alkyl or acyl Rc represents C1-6 alkyl or a heterocyclyl A is unsubstituted or substituted with 0 to 4 substituents Fn1, wherein Fn1 represents C1-6 alkyl, O═, or Rg-(CH2)0-3—, wherein Rg represents a heterocyclyl, phenyl, heteroaryl, acyl, RdO2S—, Re(Rf)N—, Re(Rf)NCO—, ReO—, ReOCO— or a protective group, wherein Rd represents C1-6 alkyl or MO— Re and Rf represent H or C1-6 alkyl, and a heterocycle having at least one nitrogen atom may be formed between Ra and Rb, between Rc and B, or between Re and Rf.
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