PROBLEM TO BE SOLVED: To provide novel cancer therapeutic means.SOLUTION: A tumor-specific immuno-enhancing agent contains as an active ingredient 1) a drug which inhibits interaction between Tim-4 and AMPKα1 in Tim-4 positive macrophage, 2) a drug which has a functional inhibitory action of AMPKα1 in the Tim-4 positive macrophage, or 3) a drug which inhibits autophagy activation in the Tim-4 positive macrophage, based on inhibiting reduced ability of tumor antigen presentation in the macrophage.COPYRIGHT: (C)2016,JPO&INPIT【課題】新たながん治療手段の提供。【解決手段】1)Tim-4陽性マクロファージでのTim-4とAMPKα1との相互作用を阻害する薬物、2)Tim-4陽性マクロファージでのAMPKα1の機能阻害作用を有する薬物、又は3)Tim-4陽性マクロファージでのオートファジー活性化を抑制する薬物、を有効成分とする、マクロファージにおける腫瘍抗原提示能低下を抑制することに基づく腫瘍特異的免疫増強剤。【選択図】なし
