Disclosed herein are methods and compositions for treating cancer. In particular, the in vivo efficacy of unconjugated anti-TfR antibodies, such as ch128.1, are disclosed herein.Linvention concerne des procédés et des compositions pour traiter des cancers. En particulier, linvention concerne lefficacité in vivo danticorps anti-TfR non conjugués, tels que ch128.1.