A fully-automatic regional citrate anticoagulation machine comprises a sampling portion, a sample injection portion, an assay and analysis portion, an administration portion, and a program control portion. The sampling portion extracts a blood sample on line and in real time and sends the blood sample to a blood sample storage purifier (22) for storage and purification. The sample injection portion conveys the blood sample in the blood sample storage purifier (22) to a sample loading slot (30) through a sample injection tube (12). The assay and analysis portion conveys, through a sample suction tube (13), the blood sample to an analyzer (14) for blood sample assay and analysis. The sampling portion, the sample injection portion, the assay and analysis portion and the administration portion are connected to the program control portion (15). The program control portion (15) controls, according to an internally-set program, operation of the sampling portion, the sample injection portion and the assay and analysis portion, and sends an instruction to the administration portion according to the data result obtained by the assay and analysis portion. The technical problems of dosage adjustment delays and high expense due to tedious and time-consuming manual calculation and operation steps in RCA methods of the prior art are resolved.La présente invention concerne une machine anticoagulation régionale au citrate entièrement automatique qui comprend une partie d'échantillonnage, une partie d'injection d'échantillon, une partie d'essai et d'analyse, une partie d'administration et une partie de commande de programme. La partie d'échantillonnage extrait un échantillon de sang en ligne et en temps réel et envoie l'échantillon de sang à un purificateur de stockage d'échantillon de sang (22) pour stockage et purification. La partie d'injection d'échantillon transporte l'échantillon de sang dans le purificateur de stockage d'échantillon de sang (22) dans un logement de chargement
