The present invention relates to a method of treating tumors wherein PAK1 is over- expressed or amplified by co-administering a PAK1 inhibitor and a second anti-hyper- proliferative agent.La presente invención se refiere a un método para tratar tumores en donde PAK1 es sobre-expresado o amplificado al co-administrar un inhibidor PAK1 y un segundo agente anti-hiperproliferativo.