The present invention provides a composition used for thermotherapy. The composition includes a carrier structure and a plurality of metal particles. The carrier structure includes a lipid layer, a positive charged polymer and a surface active polymer. The positive charged polymer and the surface active polymer are respectively dispersed on the lipid layer by non-covalent bonding. The metal particles are encapsuled in the carrier structure. The present invention also provides a producing method of the composition used for thermotherapy and a use of cancer treatment of the composition.本發明提供一種用於熱治療之組合物,其包括一載體結構以及複數金屬粒子。載體結構包括一脂質膜、一正電聚合物及一界面活性聚合物,其中,正電聚合物及界面活性聚合物係透過非共價鍵的方式佈設於脂質膜。複數金屬粒子係被載體結構包覆。本發明另提供一種用於熱治療之組合物的製造方法及上述組合物應用於癌症治療的用途。1‧‧‧組合物11‧‧‧載體結構111‧‧‧脂質膜112‧‧‧正電聚合物113‧‧‧界面活性聚合物12‧‧‧金屬粒子
