The present invention is related to surgical instruments incorporating the usage of magnets for application in minimally invasive surgery to perform abdominal surgery with a single incision through the navel which is the most widely used, this incision can also be done through some natural orifice like the vagina, mouth, etc.The present invention also describes a surgical tool to manipulate the magnetic surgical devices, a surgical apparatus to position an external magnet during surgery, a surgical probe comprising at least a magnet at one of its ends, a surgical tool to manipulate spherical magnets and washers, a cannula with a system to fasten knots and to fit a catheter and a organ surgical retractor.Generally, the invention comprises instruments to perform cholecystectomy (gallbladder removal), but they are also useful for all type of operation requiring mobilization, traction, counter-traction or also separation of abdominal organs. They can be used in several kind of surgeries, such as laparoscopy, general, gynecological, urologic surgery, etc. surgery.Predmet ovog pronalska su derivati indol-2-ona, disupstituisani na 3-poziciji, opšteformule (I), u kojoj su ~, R1, R2, R3 , R4, RS , Ar i n definisani kao u zahtjevu 1,postupak dobijanja ovih jedinjenja i njihova primjena u terapiji .
