Paramagnetic solid lipid nanoparticles (pSLN) containing amphiphilic complexes for MRI

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专利权人:

ブラッコ・イメージング・ソシエタ・ペル・アチオニ

发明人:

シモーナ・ギアーニ,アレッサンドロ・マイオッキ,キアラ・ブリオスキ,マッシモ・ヴィジガッリ,クラウディア・カベッラ,ルイージ・ミラゴリ

申请号：

JP2015530409

公开号：

JP6251744B2

申请日:

2013.09.06

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/