Method for selecting a Strain of bacteria that includes lactic acid Bacteria by the presence of an active histidine OPERON and select a strain that has an active histidine OPERON and is able to produce Histamine； and Product comprising cells of This strain.
A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.METODO PARA SELECCIONAR UNA CEPA DE BACTERIA DEL ACIDO LACTICO QUE COMPRENDE DETECTAR BACTERIAS POR LA PRESENCIA DE UN OPERON HISTIDINA ACTIVA Y SELECCIONAR UNA CEPA QUE TENGA UN OPERON HISTIDINA ACTIVA Y SEA CAPAZ DE PRODUCIR HISTAMINA； Y SUS USOS.
