A method and system for determining an angulation of a C-arm image acquisition system for a cardiac intervention is disclosed. A 3D ultrasound image including a cardiac region is received. The 3D ultrasound image is registered to a 3D coordinate system of the C-arm image acquisition system. A cardiac structure of interest is detected in the registered 3D ultrasound image. An angulation of the C-arm image acquisition system is determined based on the detected structure of interest in the registered 3D ultrasound image.
