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METHODS FOR TREATING POST-TRAUMA STRESS DISORDER
专利权人:
АЗЕВАН ФАРМАСЬЮТИКАЛЗ; ИНК. (US)
发明人:
БРАУНСТЕЙН Майкл Дж. (US)
申请号:
RU2012158025/15
公开号:
RU2012158025A
申请日:
2011.07.01
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of treating a patient with post-traumatic stress disorder, comprising the step of administering to said patient one or more compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: A is a carboxylic acid, ester or amide; B is a carboxylic acid, ester or amide; or B is an alcohol or thiol, or a derivative thereof; R is hydrogen or C-C1-6 alkyl; R is hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, halogen, haloalkyl, cyano, formyl, alkylcarbonyl or a substituent selected from the group consisting of -COR, -CONRR and -NR (COR); where R and R are each independently selected from hydrogen, alkyl, cycloalkyl, optionally containing aryl substituents or optionally containing arylalkyl substituents; or R and R together with the attached nitrogen atom form a heterocyclyl group; and where R is selected from hydrogen, alkyl, cycloalkyl, alkoxyalkyl, possibly containing aryl substituents, possibly containing arylalkyl substituents, possibly containing heteroaryl substituents, possibly containing heteroarylalkyl substituents and RRN- (C-C1-6 alkyl); R is amino, amido-, acylamide or an ureido group, which optionally contains substituents; or R represents a nitrogen-containing heterocyclyl group attached at a nitrogen atom; and R is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, alkylcarbonyl, optionally containing aryl substituents, possibly containing arylalkyl substituents, possibly containing arylhaloalkyl substituents, possibly containing arylalkoxyalkyl substituents, possibly containing arylalkenyl substituents,1. Способ лечения пациента с посттравматическим стрессовым расстройством, включающий этап введения указанному пациенту одного или более соединений формулыили их фармацевтически приемлемой соли, где:A представляет собой карбоновую кислоту, сложный эфир или амид;B представляет собой карбоновую кислоту, сложный эфир или амид; или B представляет собой спирт или тиол, или их производное;Rпредставляет собой водород или C-Cалкил;R
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