A flexible clip applier (10) includes a ratchet mechanism (68,70) adapted to locate a clip pusher (34) to a known location after deployment of a distalmost clip (202). In addition, the clip applier includes a flexible housing (12) into which a train of clips (202) may be chambered. The flexible housing is constrained from elongation when subject to tensile forces. In accord with another aspect of the invention, the jaw assembly (18,20) is adapted to have relatively high mechanical leverage which facilitates tissue compression prior to application of a clip.
