595445 Disclosed herein are injectable insulin formulations with improved stability and rapid onset of action comprising insulin in combination with a chelator and dissolution agent, and optionally additional excipients. The formulations may be for subcutaneous, intradermal or intramuscular administration. In the preferred embodiment, the formulations are administered via subcutaneous injection. In the preferred embodiment, the formulation contains human insulin, a zinc chelator such as EDTA and a dissolution agent such as citric acid or sodium citrate. These formulations are rapidly absorbed into the blood stream when administered by subcutaneous injection.
