14-membered ketolides and methods of their preparation and use

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专利权人:

President and Fellows of Harvard College

发明人:

Andrew G. Myers,Ian Bass Seiple,Ziyang Zhang

申请号：

US15517843

公开号：

US10633407B2

申请日:

2015.10.08

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macro-cyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.

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中国工程科技知识中心

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http://www.ckcest.cn/home/