JAKOBOVITS, AYA,KUCHERLAPATI, RAJU,KLAPHOLZ, SUE,MENDEZ, MICHAEL,GREEN, LARRY
申请号：
CA2616914
公开号：
CA2616914C
申请日:
1997.12.03
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (V H and V K) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies. An isolated fully human antibody is provided in accordance with the invention that binds epidermal growth factor receptor (EGFR) and inhibits the binding of EGF to EGFR.
