Christophe Blanchetot,Martine Smit,Regorius Leurs,Sven Jähnichen,Dominique Schols,Michael John Scott Saunders,Johannes Joseph Wilhelmus De Haard,Peter Vanlandschoot,Peter Verheesen
申请号：
US14627035
公开号：
US09803018B2
申请日:
2015.02.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to amino acid sequences that are directed against (as defined herein) human cellular receptors for viruses and/or bacteria such as e.g. Nanobodies specifically recognizing hCD4, hCXCR4, hCCR5, hTLR4, human alphaV integrin, human beta3 integrin, human beta1 integrin, human alpha2 integrin, hCD81, hSR-BI, hClaudin-1, hClaudin-6 and hClaudin-9, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. Amino acid sequences of the present invention may be used to prevent human cell entry of HIV, HCV, adenoviruses, hantavirus, herpesvirus, echo-virus 1 and others.
