A medical appliance securing device. In one embodiment, the device includes a pair of anchoring patches, each of the anchoring patches having an inner edge. A retaining tab extends from and interconnects the inner edges of the anchoring patches. The retaining tab has a first end fixed to the patches and a second end that is free to move relative to patches so that the retaining tab may be wrapped around at least a portion of a medical appliance. Complementary fasteners are adhered to the fixed and free ends of the retaining tab. Both the anchoring patches and the retaining tab are made up of a multi-layer material that includes a breathable non-woven fabric, a pressure-sensitive adhesive adhered to one surface of the fabric, and a moisture-barrier layer adhered to the opposite surface of the fabric.