The present invention provides an antibody that induces immune tolerance, induced lymphocytes, and a cell therapy method using the induced lymphocytes. In particular, the present invention provides an antibody that inhibits the interaction of CD80 and / or CD86 expressed on the cell surface of a certain cell with CD28 expressed on the cell surface of other cells, and does not substantially induce cytokines induced by immune activation. In a specific embodiment, the Fc portion of the antibody does not substantially produce cytokines induced by immune activation.本發明提供一種誘導免疫耐受之抗體、被誘導之淋巴球、及使用被誘導之淋巴球之細胞治療劑治療方法。本發明尤其提供一種抗體，其抑制於某一細胞之細胞表面表現之CD80及/或CD86與於其他細胞之細胞表面表現之CD28的相互作用，且實質上不誘導由免疫活化誘導之細胞激素。於特定之實施形態中，抗體之Fc部分係實質上不產生由免疫活化誘導之細胞激素之部分。
