刻痕(NOTCH)路徑傳訊抑制化合物农业专利-农业学术服务平台

发明人:: CLAY, JULIA MARIE,克雷　茱莉亚　玛丽,克雷　茱莉亞　瑪麗,EDGE, ALBERT,艾吉　亚伯特,艾吉　亞伯特,GILL, JOHN C.,吉尔　约翰Ｃ,吉爾　約翰Ｃ,HIPSKIND, PHILIP ARTHUR,希普斯金　菲利普　亚瑟,希普斯金　菲利普　亞瑟,PATEL, BHARVIN KUMAR,派特尔　巴哈瑞温　柯玛,派特爾　巴哈瑞溫　柯瑪,VAN ES, HELMUT,克雷茱莉亚玛丽,克雷茱莉亞瑪麗,艾吉亚伯特,艾吉亞伯特,吉尔约翰C,吉爾約翰C,希普斯金菲利普亚瑟,希普斯金菲利普亞瑟,派特尔巴哈瑞温柯玛,派特爾巴哈瑞溫柯瑪

摘要：: The present invention provides compounds, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing said compounds, or a pharmaceutically acceptable salt thereof, useful as a Notch pathway signaling inhibitor for the treatment of named cancers, sensorineural hearing loss caused by auditory hair cell loss, and inducing auditory hair cell generation.本發明提供可用作刻痕路徑傳訊抑制劑之化合物或其醫藥上可接受的鹽、及含該等化合物或其醫藥上可接受的鹽之醫藥組合物，用於治療指定癌症、由聽覺毛細胞損失引起之感覺神經性(sensorineural)聽力損失，及誘導聽覺毛細胞生成。