Mare Nishiura,Kenichi Ashihara,Kanehira Imai,Atsushi Muro,Tsukasa Nishikawahara
申请号：
US15906786
公开号：
US20180185437A1
申请日:
2018.02.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a granular pharmaceutical composition obtained by coating a nucleus with: (1) a layer containing a material having a damp-proofing function, and (2) a drug layer containing linaclotide, a pharmaceutically acceptable salt, or a hydrate thereof, and (3) a layer containing a material having a damp-proofing function. Also, the present invention relates to a method for manufacturing the granular pharmaceutical composition obtained by coating the nucleus with (1) the layer containing the material having a damp-proofing function, (2) the drug layer containing the linaclotide, the pharmaceutically acceptable salt, or the hydrate thereof, and (3) the layer containing the material having a damp-proofing function.
