Provided are 5-substituted quinazolinone compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.本發明提供5-取代喹唑啉酮化合物及其醫藥學上可接受之鹽、溶劑合物、籠形物、立體異構體及前藥。揭示此等化合物之使用方法及醫藥組合物。