NANOSTRUCTURED SILDENAFIL BASE, ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND CO-CRYSTALS, COMPOSITIONS OF THEM, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FILIPCSEI GENOVEVA,OTVOS ZSOLT,PONGRACZ KATALIN,DARVAS FERENC
申请号：
IN652/CHENP/2012
公开号：
IN2012CN00652A
申请日:
2012.01.18
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
The present invention is directed to nanostructured (nanoparticulated) Sildenafil base, its pharmaceutically acceptable salts and co-crystals, compositions containing them, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Sildenafil base, its pharmaceutically acceptable salts and co-crystals, compositions containing them according to the invention have an average particle size of less than about 500 nm. Sildenafil citrate is inhibiting cGMP specific phosphodiesterase type 5 (PDEV), an enzyme that regulates blood flow in the penis. The compositions of the invention are usefUl in the treatment of male or female sexual dysfunction and pUlmonary arterial hypertension (PAH).
