The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.本揭示之標的物提供結合KLB及FGFR1之抗體及其使用方法。在某些實施例中,本發明抗體包括結合至存在FGFR1上之表位(epitope)且結合至存在KLB上之表位的雙特異性抗體。