Compositions of berberine in combination with pharmacologically active organic acids, and methods of their use in treating various diseases or disorders. Compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and/or preventing various diseases or disorders. The compounds and pharmaceutical compositions can be utilized to treat various diseases or disorders, such as diabetes, diabetic complications, dyslipidemia, hyperlipidemia, obesity, metabolic syndromes, pre-diabetes, atherosclerosis, heart diseases, neurodegenerative diseases, sarcopenia, muscle atrophy, inflammation, cancer and liver diseases and conditions such as fatty liver, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cholestatic liver diseases or graft-versus-host disease of the liver. The compounds are also useful in improving liver functions in chronic viral associated liver diseases and alcohol-related liver diseases.Se describen composiciones de berberina en combinación con ácidos orgánicos farmacológicamente activos, y métodos para su uso en el tratamiento de diversas enfermedades o trastornos. Los compuestos preparados a partir de berberina y ácidos orgánicos farmacológicamente activos y preparados a partir de ácido ursodesoxicólico y bases orgánicas farmacológicamente activas, y composiciones farmacéuticas de las mismas, y métodos para su preparación y uso terapéutico en el tratamiento y/o prevención de diversas enfermedades o trastornos. Los compuestos y composiciones farmacéuticas se pueden utilizar para tratar diversas enfermedades o trastornos, tales como diabetes, complicaciones diabéticas, dislipidemia, hiperlipidemia, obesidad, síndromes metabólicos, prediabetes, ateroesclerosis, enfermedades del corazón, enfermedades neurodegenerativas, sarcopenia, atrofia muscula
