This is a pluggable plasma discharge tube device, which is comprised of a replaceable discharge tube and a hand-held shell to which the tube can be plugged in. There is a single electrode inside of the tube; there are no other electrodes outside. This electrode is connected to an output of power supply and another output of power supply is connected to the ground wire of its circuit. The input of the power supply is a 12V or lower, DC (direct current) source, or a battery. The plasma is generated via a contact-tube outside discharge, or a plasma jet from the tube, that uses working inert gas. The plasma discharge tube will produce atmospheric pressure, cold quasi-glow plasma, which can be used for sensitive surface disinfection, sterilization, as well as facial skin rejuvenation, treatment of skin tissue infections and destruction of cancer cells.