In the present invention, provided is a crude drug composition, which has effects of preventing, treating or alleviating reflux esophagitis or diseases related to skin and is safe to the human body since the composition has no toxicity. In the present invention, provide is a processed eastern prickly pear whose anti-oxidant activity and anti-inflammatory activity are improved. The present invention relates to a method for manufacturing fermented Eastern prickly pear. A pharmaceutical or food composition according to the present invention has an outstanding effect of treating or improving reflux esophagitis or diseases related to skin without adding an extra synthetic additive or physiological active substances with use of a simple process of fermenting Eastern prickly pear which is natural ingredients.본 발명은 천년초 발효물을 함유하는 역류성 식도염 또는 피부 질환의 치료, 예방 또는 완화용 의약 조성물, 또는 식품 혹은 음료 조성물에 관한 것이다.
