BRAUN, MARTIN,FARIDMOAYER, AMIRREZA,GERBER, SABINA MARIETTA,MULLER, MARKUS
申请号：
CA3086262
公开号：
CA3086262A1
申请日:
2018.12.19
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention discloses modified Staphylococcus aureus HIa proteins which show reduced tendency to aggregate, improving protein stability and yield. Said modified HIa proteins optionally also contain glycosylation site consensus sequences. The invention also discloses a conjugate comprising a modified HIa protein and an antigen (for example a Staphylococcus aureus saccharide antigen), wherein the antigen is linked to an amino acid residue of the modified HIa protein.
