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Stable tablet containing 4,5-epoxymorphinan derivative
专利权人:
Kotoe Ohta
发明人:
Kotoe Ohta,Suguru Takaki,Yasuhide Horiuchi
申请号:
US13125726
公开号:
US08829019B2
申请日:
2009.10.23
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention relates to a stable tablet comprising a 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt thereof as an effective ingredient. That is, the tablet according to the present invention comprises: (1) as the effective ingredient, a specific 4,5-epoxymorphinan derivative or a pharmacologically acceptable acid addition salt (2) sodium thiosulfate (3) at least one selected from the group consisting of saccharides and sugar alcohols and (4) crospovidone, sodium carboxymethyl starch or a mixture thereof, in which tablet the content of the aforementioned (4) is 1 to 20% by weight per unit weight containing the aforementioned effective ingredient.
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