Hadasit Medical Research Services & Development Limited
发明人:
HIGAZI, Abd,HIJAZI, Nuha
申请号：
EP13813541
公开号：
EP2869834A4
申请日:
2013.07.02
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The invention relates to an anti fibrinolytic composition comprising at least one tPA mutant that carries at least one point mutation substituting Ser481 to Ala on tPA, said mutant inhibits the fibrinolytic activity of at least one of tPA and uPA and therefore may be used for treating disorders associated with fibrinolytic processes, specifically, coagulopathies, thrombocytopenia and bleeding. The invention further provides methods and uses of the mutants of the invention.
