GA KOTARO,何 浩太郎,MORITA AIKO,森田 愛子,WATANABE SO,渡辺 壮
申请号：
JP2014197163
公开号：
JP2016069287A
申请日:
2014.09.26
申请国别(地区):
JP
年份:
2016
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide a rivastigmine-containing percutaneous absorption patch which can inhibit the production of the degradation product derived from rivastigmine, can inhibit reduction in quality over time, and can use the medicinal effect of a drug effectively and continuously.SOLUTION: The invention provides a percutaneous absorption patch consisting of a base material, drug-containing layer, and release liner, the patch containing rivastigmine, a specific acrylic pressure sensitive adhesive, and an organic acid in the drug-containing layer and also a packed body of the percutaneous absorption patch where the percutaneous absorption patch is enclosed in a packaging material under low-oxygen conditions.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】 リバスチグミン由来の分解生成物の生成を抑制し、経時的な品質の低下を抑制して、薬物の薬理効果を有効にかつ持続的に利用できるリバスチグミン含有経皮吸収型貼付製剤を提供すること。【解決手段】 支持体、薬物含有層及び剥離ライナーからなり、該薬物含有層中にリバスチグミン、特定のアクリル系粘着剤及び有機酸を含有する経皮吸収型貼付製剤。また、前記経皮吸収型貼付製剤を、包装材料中に低酸素状態で封入させた経皮吸収型貼付製剤の包装体。【選択図】 なし
