PROBLEM TO BE SOLVED: To provide a peptide which improves an expression of an antioxidation stress enzyme group by Nrf2 transcriptional activity, and to provide medicaments for diseases which can be caused by the expression of the above antioxidation stress enzyme group.SOLUTION: The invention provides a peptide consisting of an amino acid sequence in which one or some amino acids are deleted, substituted, or added and a pharmaceutical composition comprising the peptide concerned, in a peptide consisting of an amino acid sequence represented by a formula (1): (R)nLQLDEETGEFLPIQ (1) [where, n represents a natural number of 6-12], or the amino acid sequence represented by the above formula (1).COPYRIGHT: (C)2015,JPO&INPIT【課題】Nrf2の転写活性による抗酸化ストレス酵素群の発現を向上させるペプチドを提供すること、及び上記抗酸化ストレス酵素群の発現により疾患し得る医薬を提供すること。【解決手段】式(1)(R)nLQLDEETGEFLPIQ (1)[式中、nは、6~12の自然数を示す]で表されるアミノ酸配列からなるペプチド又は上記式(1)で表されるアミノ酸配列において1個又は数個のアミノ酸が欠失、置換又は付加されたアミノ酸配列からなるペプチド、及び当該ペプチドを含む医薬組成物。【選択図】なし
