LEE, JUNG HWAN,이중환,KIM, SOON HAG,김순학,KWON, MI JIN,권미진,KANG, HYUN GU,강현구,RYU, SUNG HO,류성호,KIM, JONG IN,김종인,KIM, YOUN DONG,김윤동,CHAE, YOUNG CHAN,채영찬,JANG, SUNG KEY,장승기,IM, JONG HUN,임종훈,LEE, SUN HAK,이선학,L
申请号：
KR1020127028348
公开号：
KR1020130095635A
申请日:
2010.09.15
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A nucleolin-specific aptamer is provided to function as a nucleolin inhibitor and be used as an agent suppressing the dysplasia of a cell, thereby usefully used for the treatment of hyper-proliferative disease such as cancer. CONSTITUTION: A nucleolin-specific aptamer includes a sequence in which at least one thymidine (T) existing in a sequence number 3 is respectively substituted with deformation pyrimidine nucleoside. The deformation pyrimidine nucleoside is one among deoxyuridine (dU) having a hydrophobic group in 5-position, deoxycytidine (dC), uridine (U) and cytidine (C). A sequence number 3 is NGGTGGTGGTGGTTGTGGTGGTGGTGGN. In the sequence number 3, each N is nonexistence or one nucleoside selected from a group consisting of adenosine (A), thymidine (T)/uridine (U), cytidine (C) and guanosine (G).본 발명은 뉴클레오린에 특이적으로 결합하는 향상된 G-리치 올리고뉴클레오티드(G-rich oligonucleotide) 압타머, 상기 압타머의 제조방법 및 뉴클레오린 관련 질환을 진단 및/또는 치료하는 압타머의 용도를 제공한다.
