The present invention relates to a method of controlling local release of a target material by patterning a hydrogel on a nanoporous shielding membrane, wherein the nanoporous shielding membrane (S1) comprises preparing a micro mold having a plurality of concave grooves； (S2) pouring the hydrogel solution into the micro mold； (S3) filling the hydrogel solution into a plurality of concave grooves on the micromold； (S4) covering the semi-permeable nano-porous shielding membrane on the micro mold filled with the hydrogel solution:(S5) allowing the hydrogel to be crosslinked in the micro mold covered with the nanoporous shielding film； (S6) separating the micro mold and the semi-permeable nano porous shielding film； And (S7) applying a hydrogel micropattern to the semi-permeable nanoporous shielding membrane, wherein the micromold is made of polydimethylsiloxane (PDMS), Teflon or polymethyl methacrylate (poly). (methylmethacrylate), PMMA) is prepared by electrospinning the material, the hydrogel is gelatin methacryloyl (Gel-MA), hyaluronic acid (Hyaluronic acid) or sodium alginate (Na-Alginate) At least one of the above, wherein the crosslinking is carried out by an ion crosslinking method through light crosslinking or ion exchange using light, the target material may include a bone-forming protein or drug. On the other hand, according to the present invention, not only can control the local release in the conventional protein delivery, but also prevents the entry of connective tissue at the damaged site for a certain period of time can also act as a shield to prevent the formation of scar tissue have.본 발명은 나노 다공성 차폐막에 수화젤을 패터닝하여 목표물질의 국소적 방출을 제어하는 방법에 관한 것으로서, 상기 나노 다공성 차폐막은 (S1) 여러 개의 오목한 홈이 있는 마이크로몰드를 준비하는 단계； (S2) 수화젤 용액을 상기 마이크로몰드에 붓는 단계； (S3) 상기 수화젤 용액이 상기 마이크로몰드 상의 여러 개의 오목한 홈에 채워지는 단계； (S4) 상기 수화젤 용액이 채워진 마이크로몰드 위에 반투과성 나노 다공성 차폐막을 덮는 단계: (S5) 상기 나노 다공성 차폐막이 덮힌 마이크로몰드에 상기 수화젤이 가교되도록 하는 단계； (S6) 상기 마이크로몰드와 상기 반투과성 나노 다공성 차폐막을 분리하는 단계； 및 (S7) 반투과성 나노 다공성 차
