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专利权人:
Hovione International Ltd.
发明人:
SANTOS, Jose Luis,GASPAR, Filipe
申请号:
HUE13716344
公开号:
HUE037271T2
申请日:
2013.03.28
申请国别(地区):
HU
年份:
2018
代理人:
摘要:
The present invention provides a method for producing particles having a reduced particle size distribution, which method comprises the steps of: a) providing a composition comprising particles; b) subjecting the particles in said composition to a size reduction step or to a size growth step; c) feeding said particles to a first membrane separation system to separate said particles according to size; d) recycling those particles that do not meet the size criteria back to step a); e) optionally, collecting in a collection tank the permeate of the first membrane separation system. Particles obtainable according to the method of the invention and characterized by having a near monodisperse particle size distribution are also provided. The particles are preferably characterized by having a particle size distribution with a span of less than 2.0. The invention also provides pharmaceutical compositions comprising particles according to the invention, and also apparatus for carrying out the method of the invention.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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