Zoya N. Demidenko;Mikhail V. Blagosklonny;Andrei V. Gudkov
发明人:
Mikhail V. Blagosklonny,Andrei V. Gudkov,Zoya N. Demidenko
申请号：
US13505573
公开号：
US20120283269A1
申请日:
2010.11.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides a method of suppression and/or deceleration of mammalian cellular aging. The method involves contacting mammalian cells with a composition that contains a non-genotoxic inducer of p53 (NGIP). In certain embodiments, the NCIP is a Mdm-binding agent or Mdm-2 antagonist. The NGIP can be nutlin, nutlin-3A, a nutlin analog, or a combination thereof. The invention also provides a method for reducing cellular hypertrophy in an organism by administering a composition that contains an anti-hypertrophic compound, such as nutlin, nutlin-3A, a nutlin analog, rapamycin or a rapamycin analog and combinations thereof, to the organism.
