PROBLEM TO BE SOLVED: To provide a novel composition having nerve activating action.SOLUTION: This invention relates to: a nerve activating composition containing extract of Isodon japonicus, a plant of Lamiaceae, Rabdosia, as an active ingredient a nerve activating composition in which Isodon japonicus extract is obtained using water and/or ethanol a composition having nerve activating action, discovered through an evaluation system with a change in phosphorylation ERK associated with the induction of expression of immediate-early genes in nerve cells as an index and a nerve activating composition that improves the neurotransmission functions of nerve cells having decreased activity and brings about improved cognitive functions.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2018,JPO&INPIT【課題】新規な神経活性化作用を有する組成物の提供。【解決手段】シソ科ヤマハッカ属の植物であるエンメイソウ抽出物を有効成分とする神経活性化組成物。エンメイソウ抽出物が水及び/又はエタノールによる抽出物である神経活性化組成物。神経細胞の最初期遺伝子発現誘導に関わるリン酸化ERKの変化を指標とする評価系を用いて、見いだされた神経活性化作用を有する組成物。活性が低下した神経細胞において神経伝達機能を改善し、認知機能の向上をもたらす神経活性化組成物。【選択図】図1
