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SOLID ORAL FORMULATIONS OF A PYRIDOPYRIMIDINONE
专利权人:
NOVARTIS AG
发明人:
VERMA, DAYA,TENG, YUE (HELEN),SINGH, RAJINDER,THOMPSON, DAN
申请号:
NZ59403510
公开号:
NZ594035A
申请日:
2010.01.28
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
594035 Disclosed is a pharmaceutical formulation comprising (a) (R)-2-amino-7-[4-fluoro-2-(6-methoxy-pyridin-2-yl)-phenyI]-4-methyl-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one or a pharmaceutically acceptable salt thereof which is optionally micronized to a median particle size of about 10 nm to about 40 microns; and at least one (b) a surfactant, (c) or an acid, When the surfactant is vitamin E TPGS, it may be processed by direct blending. The acid is preferably an organic acid such as succinic acid.
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