Pharmaceutically active homo dimers of opioid and other pharmaceutically active agents characterized by a single phenolic hydroxyl group wherein the respective monomers are ether linked through such groups by an ethylene residue. The dimers share the receptor pharmacology of the corresponding monomer in particular cases are non absorbed and the ether link of the dimers is particularly resistant to metabolism when administered to a subject all conferring divers advantages relative to the corresponding monomers. Exemplary of the dimers are those of buprenorphine naloxone naltrexone des venlafaxine albuterol and acetaminophen.
