William E. Klunk,Chester A. Mathis, Jr.,Yanming Wang
申请号：
US12971886
公开号：
US08404213B2
申请日:
2010.12.17
申请国别(地区):
US
年份:
2013
代理人:
摘要：
This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where accumulation of neuritic plaques are prevalent. The disease states or maladies include but are not limited to Alzheimers disease, familial Alzheimers disease, Downs Syndrome and homozygotes for the apolipoprotein E4 allele.
