The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.本發明係關於新穎細胞毒性司普力西歐史塔丁(spliceostatin)類似物及衍生物、其抗體藥物軛合體,及使用彼以治療醫學病況包括癌症之方法。