A disease management system, methods, and devices are shown and described. In one embodiment, the system includes an infusion pump and a remote controller with the ability to be paired to each other and to confirm the authenticity of instructions sent to the infusion device from the remote controller. A method to verify a wireless connection between an infusion pump and a remote controller is shown and described herein. In addition, a method of operating a diabetes management system is provided in which the system includes an infusion pump and at least a remote controller.本文展示並敘述一種疾病管理系統、方法及裝置。在一實施例中,該系統包括一輸注泵及一遠程控制器,該等具有能互相配對及確認自該遠程控制器發送至該輸注裝置的指令可靠性的能力。本文展示並敘述一種在一輸注泵與一遠程控制器之間驗證無線連接的方法。此外,尚提供一種操作糖尿病管理系統的方法,其中該系統包括一輸注泵及至少一個遠程控制器。