Disclosed herein is a framework for facilitating patient signal analysis. In accordance with one aspect, patient signal data including at least one identified cycle is segmented into at least two regions of interest, including a late potential region of interest. The late potential region of interest may be an RS, RT, S-full or T-full signal portion. At least one patient signal parameter is determined based at least in part on the segmented regions of interest. A pathology or event may be detected based on the determined patient signal parameter.
