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Nitrogen-containing heterocyclic compound and use of same
专利权人:
Junya Shirai;Hironobu Maezaki;Hideyuki Sugiyama;Taku Kamei
发明人:
Junya Shirai,Hideyuki Sugiyama,Taku Kamei,Hironobu Maezaki
申请号:
US13119743
公开号:
US08592454B2
申请日:
2009.09.18
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to a compound represented by the formulawherein ring A is a nitrogen-containing heterocycle;ring B is an aromatic ring optionally having substituent(s);ring D is an aromatic ring optionally having substituent(s);L is a group represented by the formulaR2, R3, R4a and R4b are each independently a hydrogen atom, an optionally halogenated C1-6 alkyl group or an optionally halogenated C3-6 cycloalkyl group, or R2 and R3 are optionally bonded via an alkylene chain or an alkenylene chain, or R4a and R4b are optionally bonded via an alkylene chain or an alkenylene chain;R1 is a hydrogen atom or a substituent;m and n are each independently an integer of 0 to 5;m+n is an integer of 2 to 5; and is a single bond or double bond, or a salt thereof; and the like. The compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, digestive tract diseases, central neurological disease and the like.
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