LEE, JUNG HWAN,이중환,CHAE, YOUNG CHAN,채영찬,KIM, YOUN DONG,김윤동,KANG, HYUN GU,강현구,IM, JONG HUN,임종훈,KIM, JONG IN,김종인,KIM, KI SEOK,김기석,JANG, SUNG KEY,장승기,OH, IL UNG,오일웅,CHOI, MIN JUNG,최민정,KANG, WON JUN,강원준
申请号：
KR1020110061939
公开号：
KR1020130003071A
申请日:
2011.06.24
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A DNA aptamer which specifically binds to bread cancer-related Her2(ERBB2) receptor and a composition containing the same are provided to effectively suppress and diagnose cancer.CONSTITUTION: An ERBB2 aptamer specifically binds to ERBB2 and contains 5-15 bases which are substituted with a hydrophobic functional group of a naphthyl group, a benzyl group, a pyrrolbenzyl group, or tryptophane at 5` of dUTP(deoxyuracil). The ERBB2 aptamer contains 40-100 bases including bases selected from sequence numbers 1-35. The ERBB2 aptamer contains 40-100 bases including a base of sequence number 7 or 11. The ERBB2 aptamer additionally contains 15-30 bases at 5` end, 3`end, or both ends of a base sequence selected from sequence numbers 1-35. A pharmaceutical composition for treating cancer contains the ERBB2 aptamer as an active ingredient. A composition for diagnosing cancer contains the ERBB2 aptamer as an active ingredient.COPYRIGHT KIPO 2013본 발명은 유방암 관련 Her2 (ERBB2) 수용체에 특이적으로 결합하는 DNA 압타머, 이를 유효성분으로 함유하는 암전이 억제용 조성물 및 암진단용 조성물에 관한 것으로, 상기 압타머는 기존의 항체와는 다른 결합 기작을 가짐으로써 보다 효과적으로 암 전이를 억제하고 암을 진단할 수 있는 것을 특징으로 한다.
